The environmental pressure simulation facility is crucial to the development and testing of high-performance aeroengines. During environmental pressure simulation tests of aeroengines, a large amount of uncertain high-temperature and low-pressure gas is discharged into the pressure regulation system, resulting in significant disturbances and complex coupling among compressor unites, valves and the main pipe. To analyze the surge mechanism and support controller design, a control-oriented dynamic model of pressure regulation system is established. By considering the dominant pressure dynamics of the main pipe and the dynamic characteristics of compressors and regulating valves, the original complex system is simplified into a nonlinear model suitable for control analysis and safety-oriented design. Based on the developed model, the safe operation problem of compressor units is transformed into a constrained control problem. A cooperative sliding mode control (Co-SMC) method is then proposed to ensure that the compressor pressure ratio remains within a safe range while mitigating the impact of exhaust disturbances on the pressure regulation process. The proposed method enhances the robustness of pressure regulation system and the grid-connected efficiency of compressor units while guaranteeing the stability of closed-loop system. Comparative simulations under complex operating conditions demonstrate that the proposed method significantly improves both the safety level and control performance of pressure regulation system.