A new reflective display technology, the electrowetting display (EWD), has the advantages of high contrast ratio, high reflectivity, and ultralow power consumption. The response speed of EWDs has an important influence on optical performance, and pixel structure is one of the key factors affecting the response speed of EWDs. In order to improve the response speed, a new multi-electrode pixel structure is proposed in this paper. This structure was realized by dividing the pixel into four square-shaped sub-electrodes, and a three-dimensional EWD simulation model was established. In this model, a driving voltage was first applied to one of these sub-electrodes, and the oil was ruptured. Then, its two adjacent sub-electrodes were also supplied with driving voltages, so as to spur the oil to move to a pixel corner quickly. Simulation results showed that the response speed of EWDs can be effectively improved by using the proposed multi-electrode pixel structure. Compared with a single-electrode pixel structure, the oil rupture response time of the multi-electrode pixel structure was advanced by 0.6 ms. The pixel achieved a 2.7 ms faster response time than the single-electrode pixel for reaching a 50% aperture ratio in an opening process, and the maximum aperture ratio was increased by 6.2%.