Steroids from the Soft Coral Sinularia crassa
Copyright policy )Steroids from the Soft Coral Sinularia crassa
One new sterol, crassarosterol A (1), and four new steroidal glycosides, crassarosterosides A–D (2–5) were isolated from the Formosan soft coral Sinularia crassa. The absolute configuration of 1 was determined using the Mosher’s method. The absolute configurations for the sugar moieties of 2–5 were determined by HPLC analysis on the o-tolylthiocarbamates derived from the liberated sugar after acid hydrolysis. Compounds 2 and 4 could significantly inhibit the expression of pro-inflammatory iNOS protein at 10 µM. In contrast, 1–3 were found to stimulate the expression of COX-2 protein at this concentration. Steroids 1 and 4 also showed cytotoxicity toward the selected human liver cancer cells.
QH301-705.5, Anti-Inflammatory Agents, Taiwan, Nitric Oxide Synthase Type II, Antineoplastic Agents, Article, o-tolylthiocarbamate, Inhibitory Concentration 50, Mice, Cell Line, Tumor, Neoplasms, Drug Discovery, Animals, Humans, Glycosides, Biology (General), anti-inflammatory activity, Cell Line, Transformed, Pacific Ocean, Molecular Structure, Macrophages, Stereoisomerism, Sinularia crassa, Anthozoa, Sterols, <em>Sinularia crassa</em>;<em> </em>crassarosterosides A–D; crassarosterol A; anti-inflammatory activity; <em>o</em>-tolylthiocarbamate, Cyclooxygenase 2, crassarosterosides A–D, crassarosterol A
QH301-705.5, Anti-Inflammatory Agents, Taiwan, Nitric Oxide Synthase Type II, Antineoplastic Agents, Article, o-tolylthiocarbamate, Inhibitory Concentration 50, Mice, Cell Line, Tumor, Neoplasms, Drug Discovery, Animals, Humans, Glycosides, Biology (General), anti-inflammatory activity, Cell Line, Transformed, Pacific Ocean, Molecular Structure, Macrophages, Stereoisomerism, Sinularia crassa, Anthozoa, Sterols, <em>Sinularia crassa</em>;<em> </em>crassarosterosides A–D; crassarosterol A; anti-inflammatory activity; <em>o</em>-tolylthiocarbamate, Cyclooxygenase 2, crassarosterosides A–D, crassarosterol A
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