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Mathematics
Article . 2021 . Peer-reviewed
License: CC BY
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Mathematics
Article
License: CC BY
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Mathematics
Article . 2021
Data sources: DOAJ
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A Mathematical Model for Early HBV and -HDV Kinetics during Anti-HDV Treatment

Authors: Rami Zakh; Alexander Churkin; William Bietsch; Menachem Lachiany; Scott J. Cotler; Alexander Ploss; Harel Dahari; +1 Authors

A Mathematical Model for Early HBV and -HDV Kinetics during Anti-HDV Treatment

Abstract

Hepatitis delta virus (HDV) is an infectious subviral agent that can only propagate in people infected with hepatitis B virus (HBV). HDV/HBV infection is considered to be the most severe form of chronic viral hepatitis. In this contribution, a mathematical model for the interplay between HDV and HBV under anti-HDV treatment is presented. Previous models were not designed to account for the observation that HBV rises when HDV declines with HDV-specific therapy. In the simple model presented here, HDV and HBV kinetics are coupled, giving rise to an improved viral kinetic model that simulates the early interplay of HDV and HBV during anti-HDV therapy.

Keywords

HDV-HBV coinfection, viral kinetic models, hepatitis delta virus, QA1-939, hepatitis delta virus; HDV-HBV coinfection; viral kinetic models, Mathematics

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
2
Average
Average
Average
gold