Plithogenic set is an extension of the crisp set, fuzzy set, intuitionistic fuzzy set, and neutrosophic sets, whose elements are characterized by one or more attributes, and each attribute can assume many values. Each attribute has a corresponding degree of appurtenance of the element to the set with respect to the given criteria. In order to obtain a better accuracy and for a more exact exclusion (partial order), a contradiction or dissimilarity degree is defined between each attribute value and the dominant attribute value. In this paper, entropy measures for plithogenic sets have been introduced. The requirements for any function to be an entropy measure of plithogenic sets are outlined in the axiomatic definition of the plithogenic entropy using the axiomatic requirements of neutrosophic entropy. Several new formulae for the entropy measure of plithogenic sets are also introduced. The newly introduced entropy measures are then applied to a multi-attribute decision making problem related to the selection of locations.