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doi: 10.3390/math8020293
handle: 10216/126870 , 10400.22/19470
We study the equilibria of an Ordinary Differencial Equation (ODE) system where CD4 + effector or helper T cells and Regulatory T cells (Tregs) are present. T cells trigger an immune response in the presence of their specific antigen. Regulatory T cells (Tregs) play a role in limiting auto-immune diseases due to their immune-suppressive ability. Here, we present explicit exact formulas that give the relationship between the concentration of T cells, the concentration of Tregs, and the antigenic stimulation of T cells, when the system is at equilibria, stable or unstable. We found a parameter region of bistability, limited by two thresholds of antigenic stimulation of T cells (hysteresis). Moreover, there are values of the slope parameter of the tuning for which an isola-center bifurcation appears, and, for some other values, there is a transcritical bifurcation. We also present time evolutions of the ODE system.
cd4<sup>+</sup> tregs, Health sciences, Medical and Health sciences, Ciências médicas e da saúde, eigenvalues, Eigenvalues, ode model, CD4<sup>+</sup> T cells, CD4+ T cells, CD4+ Tregs, ODE model, bifurcation, Medical and Health sciences, QA1-939, Bifurcation, Ciências da Saúde, Ciências médicas e da saúde, cd4<sup>+</sup> t cells, CD4<sup>+</sup> Tregs, Mathematics
cd4<sup>+</sup> tregs, Health sciences, Medical and Health sciences, Ciências médicas e da saúde, eigenvalues, Eigenvalues, ode model, CD4<sup>+</sup> T cells, CD4+ T cells, CD4+ Tregs, ODE model, bifurcation, Medical and Health sciences, QA1-939, Bifurcation, Ciências da Saúde, Ciências médicas e da saúde, cd4<sup>+</sup> t cells, CD4<sup>+</sup> Tregs, Mathematics
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