The in situ stress state of deep surrounding rock is critically important for mine safety and resource extraction. This study focuses on a lead–zinc mine in Yunnan Province, China, with the objective of characterizing the distribution of the deep in situ stress field. A self-developed digital wireless acquisition system for in situ stress measurement with dual temperature compensation was emplo6yed to conduct measurements at eight underground points. Based on the measured data, the in situ stress field was inverted using the finite difference method combined with multiple linear regression, and a three-dimensional geological model of the mining area was established. The results indicate that the stress field is predominantly governed by horizontal tectonic stress, with the principal stresses showing an approximately linear increase with depth. The average relative error between the inverted and measured stress field values was 7.74%. Finally, stress parameters at key underground locations derived from the inversion model were applied in numerical simulations, providing data support for the engineering design and safety assessment in deep mining of this lead–zinc mine.