This article introduces the theory of three-variable q-truncated exponential Gould–Hopper-based Appell polynomials by employing a generating function approach that incorporates q-calculus functions. This study further explores these polynomials by using a computational algebraic approach. The determinant form, recurrences, and differential equations are proven. Relationships with the monomiality principle are given. Finally, graphical representations are presented to illustrate the behavior and potential applications of the three-variable q-truncated exponential Gould–Hopper-based Appell polynomials.