In this study, we consider the two-variable q-general polynomials and derive some properties. By using these polynomials, we introduce and study the theory of two-variable q-general Appell polynomials (2VqgAP) using q-operators. The effective use of the q-multiplicative operator of the base polynomial produces the generating equation for 2VqgAP involving the q-exponential function. Furthermore, we establish the q-multiplicative and q-derivative operators and the corresponding differential equations. Then, we obtain the operational, explicit and determinant representations for these polynomials. Some examples are constructed in terms of the two-variable q-general Appell polynomials to illustrate the main results. Finally, graphical representations are provided to illustrate the behavior of some special cases of the two-variable q-general Appell polynomials and their potential applications.