By developing a robust control strategy based on the differential flatness concept, this paper presents a solution for the bidirectional trajectory tracking task in the “full-bridge Buck inverter–DC motor” system. The robustness of the proposed control is achieved by taking advantage of the differential flatness property related to the mathematical model of the system. The performance of the control, designed via the flatness concept, is verified in two ways. The first is by implementing experimentally the flatness control and proposing different shapes for the desired angular velocity profiles. For this aim, a built prototype of the “full-bridge Buck inverter–DC motor” system, along with Matlab–Simulink and a DS1104 board from dSPACE are used. The second is via simulation results, i.e., by programming the system in closed-loop with the proposed control algorithm through Matlab–Simulink. The experimental and the simulation results are similar, thus demonstrating the effectiveness of the designed robust control even when abrupt electrical variations are considered in the system.