Quantifying In-Host Quasispecies Evolution
Copyright policy )Quantifying In-Host Quasispecies Evolution
What takes decades, centuries or millennia to happen with a natural ecosystem, it takes only days, weeks or months with a replicating viral quasispecies in a host, especially when under treatment. Some methods to quantify the evolution of a quasispecies are introduced and discussed, along with simple simulated examples to help in the interpretation and understanding of the results. The proposed methods treat the molecules in a quasispecies as individuals of competing species in an ecosystem, where the haplotypes are the competing species, and the ecosystem is the quasispecies in a host, and the evolution of the system is quantified by monitoring changes in haplotype frequencies. The correlation between the proposed indices is also discussed, and the R code used to generate the simulations, the data and the plots is provided. The virtues of the proposed indices are finally shown on a clinical case.
Evolució molecular, Distributions similarity, quasispecies fitness partition, Virus - Reproducció, Quasispecies evolution, Quasispecies fitness partition, PHENOMENA AND PROCESSES::Genetic Phenomena::Genetic Variation::Quasispecies, Article, viral treatment, Viral treatment, Evolution, Molecular, Quasispecies, distributions similarity, Mutagenesis, quasispecies evolution, FENÓMENOS Y PROCESOS::fenómenos genéticos::variación genética::cuasiespecies, Humans, PHENOMENA AND PROCESSES::Genetic Phenomena::Biological Evolution::Evolution, Molecular, FENÓMENOS Y PROCESOS::fenómenos genéticos::evolución biológica::evolución molecular, mutagenesis, Ecosystem
Evolució molecular, Distributions similarity, quasispecies fitness partition, Virus - Reproducció, Quasispecies evolution, Quasispecies fitness partition, PHENOMENA AND PROCESSES::Genetic Phenomena::Genetic Variation::Quasispecies, Article, viral treatment, Viral treatment, Evolution, Molecular, Quasispecies, distributions similarity, Mutagenesis, quasispecies evolution, FENÓMENOS Y PROCESOS::fenómenos genéticos::variación genética::cuasiespecies, Humans, PHENOMENA AND PROCESSES::Genetic Phenomena::Biological Evolution::Evolution, Molecular, FENÓMENOS Y PROCESOS::fenómenos genéticos::evolución biológica::evolución molecular, mutagenesis, Ecosystem
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