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Kisspeptin and Testicular Function—Is It Necessary?

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 22 Apr 2020 English Publisher:MDPI AGJournal:International Journal of Molecular Sciences, volume 21, page 2,958 (eissn: 1422-0067, Copyright policy )
Authors: Aditi Sharma; Thilipan Thaventhiran; Suks Minhas; Waljit S. Dhillo; Channa N. Jayasena;

doi: 10.3390/ijms21082958

pmid: 32331420

pmc: PMC7216047

handle: 10044/1/85092

Kisspeptin and Testicular Function—Is It Necessary?

Abstract

The role of kisspeptin in stimulating hypothalamic GnRH is undisputed. However, the role of kisspeptin signaling in testicular function is less clear. The testes are essential for male reproduction through their functions of spermatogenesis and steroidogenesis. Our review focused on the current literature investigating the distribution, regulation and effects of kisspeptin and its receptor (KISS1/KISS1R) within the testes of species studied to date. There is substantial evidence of localised KISS1/KISS1R expression and peptide distribution in the testes. However, variability is observed in the testicular cell types expressing KISS1/KISS1R. Evidence is presented for modulation of steroidogenesis and sperm function by kisspeptin signaling. However, the physiological importance of such effects, and whether these are paracrine or endocrine manifestations, remain unclear.

Related Organizations
Keywords

LH, EXPRESSION, Male, Biochemistry & Molecular Biology, GPR54, Chemistry, Multidisciplinary, Sertoli cells, 0699 Other Biological Sciences, testes, 610, Leydig cells, Review, kisspeptin, spermatozoa, KISS-1, FSH, 0399 Other Chemical Sciences, Testis, Animals, Humans, HYPOGONADOTROPIC HYPOGONADISM, SPERMATOGENESIS, kisspeptin receptor, Spermatogenesis, GERM-CELL PROGRESSION, 0604 Genetics, Kisspeptins, Multidisciplinary, Science & Technology, Chemical Physics, RECEPTOR, METASTASIS SUPPRESSOR GENE, LOCAL REGULATOR, spermatogenesis, 620, Chemistry, Gene Expression Regulation, Physical Sciences, testosterone, Steroids, Life Sciences & Biomedicine, SPERM, Signal Transduction

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    		 44
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
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    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
44
Top 10%
Top 10%
Top 10%
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