Copper Binding Features of Tropomyosin-Receptor-Kinase-A Fragment: Clue for Neurotrophic Factors and Metals Link
Copyright policy )Copper Binding Features of Tropomyosin-Receptor-Kinase-A Fragment: Clue for Neurotrophic Factors and Metals Link
The nerve growth factor (NGF) is a neurotrophin essential for the development and maintenance of neurons, whose activity is influenced by copper ions. The NGF protein exerts its action by binding to its specific receptor, TrkA. In this study, a specific domain of the TrkA receptor, region 58–64, was synthesized and its copper(II) complexes characterized by means of potentiometric and spectroscopic studies. The two vicinal histidine residues provide excellent metal anchoring sites and, at physiological pH, a complex with the involvement of the peptide backbone amide nitrogen is the predominant species. The TrkA peptide is competitive for metal binding with analogous peptides due to the N-terminal domain of NGF. These data provide cues for future exploration of the effect of metal ions on the activity of the NGF and its specific cellular receptor.
- National Research Council Sri Lanka
- National Research Council Italy
- Institute of Crystallography Italy
- University of Pisa Italy
- Institute of Biostructure and Bioimaging Italy
NGF, Binding Sites, receptor, neurotrophin, Track A, metal complexes, peptide, Article, copper; metal complexes; neurotrophin; peptide; receptor, potentiometry, copper, Nerve Growth Factor, Humans, Receptor, trkA, Peptides, Copper, Protein Binding
NGF, Binding Sites, receptor, neurotrophin, Track A, metal complexes, peptide, Article, copper; metal complexes; neurotrophin; peptide; receptor, potentiometry, copper, Nerve Growth Factor, Humans, Receptor, trkA, Peptides, Copper, Protein Binding
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