Retinoid X Receptor Antagonists

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type , Preprint 13 Jun 2018 English Publisher:MDPI AGJournal:International Journal of Molecular Sciences, volume 19, page 2,354 (eissn: 1422-0067,

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Authors: Masaki Watanabe; Hiroki Kakuta;

doi: 10.3390/ijms19082354 , 10.20944/preprints201806.0208.v1

pmid: 30103423

pmc: PMC6121510

Retinoid X Receptor Antagonists

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Abstract

Retinoid X receptor (RXR) antagonists are not only useful as chemical tools for biological research, but are also candidate drugs for the treatment of various diseases, including diabetes and allergies, although no RXR antagonist has yet been approved for clinical use. In this review, we present a brief overview of RXR structure, function, and target genes, and describe currently available RXR antagonists, their structural classification, and their evaluation, focusing on the latest research.

Related Organizations

Okayama University
Japan

Keywords

Retinoid X Receptors, Diabetes Mellitus, Hypersensitivity, Animals, Humans, Review, pharmacology_toxicology

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