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Non-Coding RNAs and Cancer

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 19 Aug 2013 English Publisher:MDPI AGJournal:International Journal of Molecular Sciences, volume 14, pages 17,085-17,110 (eissn: 1422-0067,

Authors: Federica Calore; Michela Garofalo; Francesca Lovat;

doi: 10.3390/ijms140817085

pmid: 23965974

pmc: PMC3759953

Non-Coding RNAs and Cancer

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Abstract

The discovery of the biological relevance of non-coding RNA (ncRNAs) molecules represents one of the most significant advances in contemporary molecular biology. Expression profiling of human tumors, based on the expression of miRNAs and other short or long ncRNAs, has identified signatures associated with diagnosis, staging, progression, prognosis, and response to treatment. In this review we will discuss the recent remarkable advancement in the understanding the biological functions of human ncRNAs in cancer, the mechanisms of expression and the therapeutic potential.

Related Organizations

The Ohio State University
United States
The Ohio State University at Marion
United States

Keywords

Gene Expression Regulation, Neoplastic, RNA, Untranslated, Carcinogenesis, Neoplasms, Animals, Humans, Genes, Tumor Suppressor, Review

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	55
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%