We study the existence of Killing vector fields for right-invariant metrics on low-dimensional Lie groups. Specifically, Lie groups of dimension two, three and four are considered. Before attempting to implement the differential conditions that comprise Killing’s equations, the metric is reduced as much as possible by using the automorphism group of the Lie algebra. After revisiting the classification of the low-dimensional Lie algebras, we review some of the known results about Killing vector fields on Lie groups and add some new observations. Then we investigate indecomposable Lie algebras and attempt to solve Killing’s equations for each reduced metric. We introduce a matrix MM, that results from the integrability conditions of Killing’s equations. For n=4, the matrix MM is of size 20×6. In the case where MM has maximal rank, for the Lie group problem considered in this article, only the left-invariant vector fields are Killing. The solution of Killing’s equations is performed by using MAPLE, and knowledge of the rank of MM can help to confirm that the solutions found by MAPLE are the only linearly independent solutions. After finding a maximal set of linearly independent solutions, the Lie algebra that they generate is identified to one in a standard list.