A Rotary-Pulsation Apparatus (RPA), also known in the literature as a Rotational Hydrodynamic Cavitation Reactor (RHCR), is a device which typically consists of a rotating mechanism that generates pulsations or vibrations within a fluid. This can be achieved through various means such as mechanical agitation, pneumatic pulses, or hydraulic forces. It is widely used in food, chemical, pharmaceutical, and microbiological industries to improve the mixing of different fluids, dispersion, pasteurization, and sterilization. In the present paper, a CFD study was conducted to develop and optimize the geometry of the RPA’s rotor and stator to induce cavitation in the fluid flow. The effect of cavitation has the potential to improve dispersion and emulsion properties and to significantly reduce operation pressure, in comparison to conventional mixing systems.