The physical and chemical properties of poplar clones largely determine their suitability for different applications. The main objective of this study was to investigate clonal variation in four hybrid poplar clones grown at three sites in North China and identify the superior clone. Study materials were collected from four clones of hybrid white poplar: Populus tomentosa “LM50”, used as the control; two clones (Yiyang-1 and Yiyang-2), new hybrids of (P. tomentosa × P. bolleana) × P. tomentosa “Truncata”; and Yiyang-3, a new hybrid of (P. tomentosa × P. bolleana) × P. tomentosa “LM50”. In total, 192 individuals from four hybrid clones were randomly chosen for sampling. The growth traits of four 7-year-old clones were examined at three sites. We also measured the wood properties of four 6-year-old clones at the Fengfeng nursery. Variation in the growth traits and the ranking of stem volumes differed among sites. Fiber traits and wood chemical components showed significant interclonal variation. With regard to the comprehensive growth rate, cellulose content, holocellulose content, and fiber traits, Yiyang-1 exhibited the best performance among the four hybrid poplar clones, indicating its utility as a raw material for pulp and papermaking.