This paper presents a novel voltage differencing transconductance amplifier (VDTA)-based mixed-mode inverse filter capable of operating in voltage mode, transadmittance mode, transimpedance mode, and current mode using a single topology. The proposed configuration employs only three VDTAs with two resistors and three capacitors, offering low component count, high input/output impedance flexibility, and no requirement for component matching. It simultaneously realizes first-order inverse lowpass and highpass, as well as second-order inverse bandpass responses. A comprehensive non-ideal analysis, which includes the effects of VDTA parasitic impedances, determines the practical operating frequency range. The design is validated through PSPICE simulations using 0.18 μm CMOS technology, showing close alignment between theoretical predictions and simulation results, with cutoff frequencies of approximately 1.60 MHz and low power consumption of 0.972 mW. Further analyses confirm orthogonal tuning capability, acceptable temperature stability, and robustness against component tolerances. In a practical application, the proposed inverse filter is employed to implement a mixed-mode PID controller, which significantly improves transient response characteristics by reducing rise time, settling time, and steady-state error. These findings highlight the effectiveness and versatility of the proposed design for analog signal processing and control system applications.