This study introduces a low-power analog integrated Euclidean distance radial basis function classifier. The high-level architecture is composed of several Manhattan distance circuits in connection with a current comparator circuit. Notably, each implementation was designed with modularity and scalability in mind, effectively accommodating variations in the classification parameters. The proposed classifier’s operational principles are meticulously detailed, tailored for low-power, low-voltage, and fully tunable implementations, specifically targeting biomedical applications. This design methodology materialized within a 90 nm CMOS process, utilizing the Cadence IC Suite for the comprehensive management of both the schematic and layout design aspects. During the verification phase, post-layout simulation results were meticulously cross-referenced with software-based classifier implementations. Also, a comparison study with related analog classifiers is provided. Through the simulation results and comparative study, the design architecture’s accuracy and sensitivity were effectively validated and confirmed.