Earth observation data provide useful information for the monitoring and management of vegetation- and land-related resources. The Framework for Operational Radiometric Correction for Environmental monitoring (FORCE) was used to download, process and composite Sentinel-2 data from 2018–2020 for Uganda. Over 16,500 Sentinel-2 data granules were downloaded and processed from top of the atmosphere reflectance to bottom of the atmosphere reflectance and higher-level products, totalling > 9 TB of input data. The output data include the number of clear sky observations per year, the best available pixel composite per year and vegetation indices (mean of EVI and NDVI) per quarter. The study intention was to provide analysis-ready data for all of Uganda from Sentinel-2 at 10 m spatial resolution, allowing users to bypass some basic processing and, hence, facilitate environmental monitoring.