This paper discusses the “what”, “why”, and “how” of the issue of “discipline informatization”. Since the Renaissance, the humanities and social sciences established under the guidance of physical-mathematical methods, such as Comte’s “social physics”, have focused mainly on the material characteristics and information carriers of cultural phenomena. Although they have gained much, they have basically failed to grasp the central axis, baseline, and link of “social information”. Therefore, the authors of this paper take the growth of natural sciences as a reference and focus on the discipline informatization of the humanities and social sciences.