Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments
Copyright policy )Roles of Farnesyl-Diphosphate Farnesyltransferase 1 in Tumour and Tumour Microenvironments
Farnesyl-diphosphate farnesyltransferase 1 (FDFT1, squalene synthase), a membrane-associated enzyme, synthesizes squalene via condensation of two molecules of farnesyl pyrophosphate. Accumulating evidence has noted that FDFT1 plays a critical role in cancer, particularly in metabolic reprogramming, cell proliferation, and invasion. Based on these advances in our knowledge, FDFT1 could be a potential target for cancer treatment. This review focuses on the contribution of FDFT1 to the hallmarks of cancer, and further, we discuss the applicability of FDFT1 as a cancer prognostic marker and target for anticancer therapy.
- Dongguk University Korea (Republic of)
farnesyl-diphosphate farnesyltransferase 1, lipid rafts, QH573-671, Drug Evaluation, Preclinical, Antineoplastic Agents, Review, Structure-Activity Relationship, Cholesterol, Farnesyl-Diphosphate Farnesyltransferase, cholesterol synthesis, Neoplasms, tumour progression, Tumor Microenvironment, Animals, Humans, Disease Susceptibility, Enzyme Inhibitors, Cytology, prognostic marker
farnesyl-diphosphate farnesyltransferase 1, lipid rafts, QH573-671, Drug Evaluation, Preclinical, Antineoplastic Agents, Review, Structure-Activity Relationship, Cholesterol, Farnesyl-Diphosphate Farnesyltransferase, cholesterol synthesis, Neoplasms, tumour progression, Tumor Microenvironment, Animals, Humans, Disease Susceptibility, Enzyme Inhibitors, Cytology, prognostic marker
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