CD46 Genetic Variability and HIV-1 Infection Susceptibility
Copyright policy )CD46 Genetic Variability and HIV-1 Infection Susceptibility
CD46 is the main receptor for complement protein C3 and plays an important role in adaptive immune responses. CD46 genetic variants are associated with susceptibility to several infectious and autoimmune diseases. Additionally, CD46 function can be subverted by HIV-1 to evade attack by complement, a strategy shared by viruses of other families. We sought to determine the association between CD46 gene variants and HIV-1 acquired through intravenous drug use (IDU) and sexual routes (n = 823). Study subjects were of European ancestry and were HIV-1 infected (n = 438) or exposed but seronegative (n = 387). Genotyping of the rs2796265 SNP located in the CD46 gene region was done by allele-specific real-time PCR. A meta-analysis merging IDU and sexual cohorts indicates that the minor genotype (CC) was associated with increased resistance to HIV-1 infection OR = 0.2, 95% CI (0.07–0.61), p = 0.004. The HIV-1-protective genotype is correlated with reduced CD46 expression and alterations in the ratio of CD46 mRNA splicing isoforms.
- Hospital Universitario Reina Sofía Spain
- University of California, Irvine United States
- Hospital Universitario Reina Sofía Spain
- University of Milan Italy
- University of Córdoba (Spain) Spain
Male, Inmunidad adaptativa, Expression, HIV Infections, Dendritic cells, Substance Misuse, HESN, Nitric-oxide, Gene Frequency, Natural-resistance, RNA Isoforms, 2.1 Biological and endogenous factors, HIV exposed seronegative, Protein Isoforms, complement, Aetiology, VIH‑1, Substance Abuse, Intravenous, CD46, Isoformas de ARN mensajero, Substance Abuse, Single Nucleotide, Complement C3, Infectious Diseases, Recombinant glycoprotein-120 vaccine, HIV/AIDS, CD46; complement; HESN; HIV exposed seronegative; HIV-1, Female, Infection, Intravenous, Complement regulatory proteins, Biotechnology, Receptor, 570, Genotype, Variación genética, Real-Time Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Article, Association, Membrane Cofactor Protein, Clinical Research, HIV Seronegativity, 616, Genetics, Humans, Genetic Predisposition to Disease, RNA, Messenger, Polymorphism, QH573-671, Individuals, Immunity, Genetic Variation, Receptores de complemento, Good Health and Well Being, Gene Expression Regulation, HIV-1, <i>CD46</i>, Cytology, Polymorphisms
Male, Inmunidad adaptativa, Expression, HIV Infections, Dendritic cells, Substance Misuse, HESN, Nitric-oxide, Gene Frequency, Natural-resistance, RNA Isoforms, 2.1 Biological and endogenous factors, HIV exposed seronegative, Protein Isoforms, complement, Aetiology, VIH‑1, Substance Abuse, Intravenous, CD46, Isoformas de ARN mensajero, Substance Abuse, Single Nucleotide, Complement C3, Infectious Diseases, Recombinant glycoprotein-120 vaccine, HIV/AIDS, CD46; complement; HESN; HIV exposed seronegative; HIV-1, Female, Infection, Intravenous, Complement regulatory proteins, Biotechnology, Receptor, 570, Genotype, Variación genética, Real-Time Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Article, Association, Membrane Cofactor Protein, Clinical Research, HIV Seronegativity, 616, Genetics, Humans, Genetic Predisposition to Disease, RNA, Messenger, Polymorphism, QH573-671, Individuals, Immunity, Genetic Variation, Receptores de complemento, Good Health and Well Being, Gene Expression Regulation, HIV-1, <i>CD46</i>, Cytology, Polymorphisms
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