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Proteolytic Cleavage of Receptor Tyrosine Kinases

Name: Proteolytic Cleavage of Receptor Tyrosine Kinases
Creator: Hao Huang
Keywords: 0301 basic medicine, 0303 health sciences, metalloprotease, secretase, caspase, proteolytic cleavage, Receptor Protein-Tyrosine Kinases, protease, Review, Microbiology

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 29 Apr 2021 English Publisher:MDPI AGJournal:Biomolecules, volume 11, page 660 (eissn: 2218-273X,

Authors: Hao Huang;

doi: 10.3390/biom11050660

pmid: 33947097

pmc: PMC8145142

Proteolytic Cleavage of Receptor Tyrosine Kinases

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Abstract

The receptor tyrosine kinases (RTKs) are a large family of cell-surface receptors, which are essential components of signal transduction pathways. There are more than fifty human RTKs that can be grouped into multiple RTK subfamilies. RTKs mediate cellular signaling transduction, and they play important roles in the regulation of numerous cellular processes. The dysregulation of RTK signaling is related to various human diseases, including cancers. The proteolytic cleavage phenomenon has frequently been found among multiple receptor tyrosine kinases. More and more information about proteolytic cleavage in RTKs has been discovered, providing rich insight. In this review, we summarize research about different aspects of RTK cleavage, including its relation to cancer, to better elucidate this phenomenon. This review also presents proteolytic cleavage in various members of the RTKs.

Related Organizations

Harvard University
United States
Dana-Farber Cancer Institute
United States
Harvard Medical School
United States

Keywords

metalloprotease, secretase, caspase, proteolytic cleavage, Receptor Protein-Tyrosine Kinases, protease, Review, Microbiology, QR1-502, Gene Expression Regulation, Neoplastic, Neoplasms, Proteolysis, receptor tyrosine kinase, Humans, Signal Transduction

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	15
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%