There has been an insurgence of allergic respiratory diseases such as asthma and rhinitis in industrialized countries in the last few decades as a result of the interaction between air pollutants and pollen, which has become a global and dramatic health problem. Air pollutants such as nitrogen dioxide, sulfur dioxide, ozone, and carbon dioxide affect the physical, chemical and biological properties of pollen such as the pollen content, production, and allergenicity, exacerbating symptoms in vulnerable subjects. When investigating these interactions and their effects, the environmental impact of climate change, weather variables and urbanization should be taken into account as well as the pollen species, type of pollutant, conditions of exposure, and individual susceptibility. Up to 25% of asthma adult cases are work-related, because several categories of workers in different sectors are exposed to aeroallergens and outdoor air pollutants. Thus, in this study, we evaluated the significant impacts of occupational allergies on worker’s health and quality of life. In summary, to assess the effect of interactions between air pollutants and pollen on public and occupational health, all the factors that play a role in this context will be investigated, including environmental factors, individual susceptibility in relation to pollen species, type of pollutants, and conditions of exposure.