This article focuses on activities addressed in the European project hydrogen lightweight & innovative tank for zero-emission aircraft, H2ELIOS. The authors propose a preliminary approach oriented to the design of a structural health monitoring SHM system conceived for a cryo-tank liquid hydrogen storage for medium range vehicles. The system was ideated to be installed on board and operating during service, to provide early detection and localization of potential damage, critical both in terms of safety and maintenance. The use of optical fibers for strain measurement is justified, on one hand, by the capability of pure silica fiber to prevent hydrogen darkening effects and, on the other hand, by the absence of metal components, which eliminates the risk of embrittlement. In detail, distributed and fiber Bragg grating FBG sensors designed for this specific application have demonstrated reliable monitoring capabilities, even after exposure to hydrogen and at cryogenic temperatures. Furthermore, another key contribution of this preliminary activity is the analysis of thermoplastic material faults by correlating damage characteristics with static and dynamic response. This is due to the fact that the investigated physics strongly depend on the nature of occurring damage. Achievements lie in the demonstrated ability to assess the health status of the reference composite structure, establishing the first steps for a future qualification of the proprietary system, made of commercial and original hardware and software.