When mineral resources are extracted using underground mining methods in hilly regions, landslides or slope failures can be induced frequently. In this study, slope collapse disasters in mountain mining areas were analyzed. The model test and numerical simulation of the slope impacted by repeated mining were carried out. The crack evolution and failure process were analyzed to reveal the instability mechanism. The results show that the rock mass would topple to the inside of the slope first, when the subsidence of overlying rock was induced by the mining of the upper coal seam. When repeated mining was performed in the lower coal seam, the mining induced macro-cracks that could connect with natural fissures, inducing the outward displacement of the slope. Then, the rock mass at the foot of the slope has to bear the upper load, which is also squeezed out by the collapsed rock mass, forming the potential slip zone. Finally, the instability is caused by the shear slip of the slope toe rock mass. Therefore, the instability evolution of the slope under underground repeated mining disturbance can be divided into four stages as follows: roof caving and overlaying rock subsidence, joint rock toppling, fracture penetration, and slope toe shearing and slope slipping.