There is evidence for the involvement of mitochondrial dysfunction, oxidative stress, ferroptosis, and inflammation in the pathogenesis of obesity. This, in turn, indicates a novel potential therapeutic role for supplemental coenzyme Q10 (CoQ10) in the management of obesity, due to the role of CoQ10 in promoting normal mitochondrial function, as an antioxidant, and as an anti-ferroptotic and anti-inflammatory agent. In the present article we have, therefore, reviewed the potential role of CoQ10 in the prevention and treatment of obesity. A potential role for supplementary CoQ10 (in combination with selenium) in preserving skeletal muscle mass in obese individuals undergoing weight loss procedures is also discussed.