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Antioxidants
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Antioxidants
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The Relationship between Cancer and Paraoxonase 1

descriptionPublicationkeyboard_double_arrow_right Article , Conference object 31 Mar 2022 English Publisher:MDPI AGJournal:Antioxidants, volume 11, page 697 (eissn: 2076-3921, Copyright policy )
Authors: Irma Martha Medina-Díaz; Néstor Ponce-Ruíz; Aurora Elizabeth Rojas-García; José Francisco Zambrano-Zargoza; Yael Y. Bernal-Hernández; Cyndia Azucena González-Arias; Briscia S. Barrón-Vivanco; +1 Authors

doi: 10.3390/antiox11040697

pmid: 35453382

pmc: PMC9028432

The Relationship between Cancer and Paraoxonase 1

Abstract

Extensive research has been carried out to understand and elucidate the mechanisms of paraoxonase 1 (PON1) in the development of diseases including cancer, cardiovascular diseases, neurological diseases, and inflammatory diseases. This review focuses on the relationship between PON1 and cancer. The data suggest that PON1, oxidative stress, chronic inflammation, and cancer are closely linked. Certainly, the gene expression of PON1 will remain challenging to study. Therefore, targeting PON1, redox-sensitive pathways, and transcription factors promise prevention and therapy in the development of several diseases, including cancer.

Related Organizations
Keywords

inflammation, cancer, oxidative stress, transcriptional factors, Therapeutics. Pharmacology, RM1-950, Review, PON1, PON1 activity

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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
34
Top 10%
Top 10%
Top 1%
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gold
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Cancer Research