With the estimated high prevalence in the population, the two symptoms of pain and depression threaten the well-being of millions worldwide. Researches of the two symptoms increased year by year. Top-cited studies will help to understand the achievement and guide researchers toward the direction of the research field. However, it is unclear for researches in the field of pain and depression. In this paper, we reviewed the bibliometric characteristics of the top-cited papers about pain and depression. We will review the evidence of authorship, country of origin, institution, journal, study type, and publication year for the 100 top-cited studies on pain and depression based on the Web of Science Core collection. We also highlight studies with the highest cited times. Our study concluded that pain and depression were correlated, which may share common biological pathways.