Skeletal muscle inflammation is triggered by multiple physiological and pathological processes. Resident immune cells such as macrophages and dendritic cells respond to the inflammatory state of skeletal muscle, and circulating immune cells can be recruited to muscle tissue (Pillon et al., 2013). Skeletal muscle adaptation depends on sequential stages of degeneration, inflammation, and regeneration (Chazaud, 2016). This remodeling process results from a finely tuned orchestration of cellular, molecular and metabolic responses involving both muscle and non-muscle cells (inflammatory cells, endothelial cells, fibro-adipogenic cells, pericytes). If unbalanced, this response leads to muscle atrophy, and/or fibrosis. This Research Topic on immunometabolism incorporates reviews and original studies to elucidate the many implications of skeletal muscle inflammation in metabolism, health, and disease.