Macrophages in homeostatic immune function
Copyright policy )Macrophages in homeostatic immune function
Macrophages are not only involved in inflammatory and anti-infective processes, but also play an important role in maintaining tissue homeostasis. In this review, we summarize recent evidence investigating the role of macrophages in controlling angiogenesis, metabolism as well as salt and water balance. Particularly, we summarize the importance of macrophage tonicity enhancer binding protein (TonEBP, also termed nuclear factor of activated T-cells 5 [NFAT5]) expression in the regulation of salt and water homeostasis. Further understanding of homeostatic macrophage function may lead to new therapeutic approaches to treat ischemia, hypertension and metabolic disorders.
- Vanderbilt University United States
- University of Melbourne Australia
- University of Erlangen-Nuremberg Germany
- Vanderbilt University School of Medicine United States
- University of Erlangen-Nuremberg Germany
tonicity enhance binding protein (TonEBP)/nuclear factor of activated T-cells 5(NFAT5), peroxisome proliferator activator receptor (PPAR), Physiology, macrophage polarization, Macrophages, Peroxisome Proliferator-Activated Receptors, Sodium, Na+ storage, 610, Lipid Metabolism, angiogenesis, Adipose Tissue, Cardiovascular and Metabolic Diseases, arteriogenesis, DDC Classification::6 Technik, Medizin, angewandte Wissenschaften :: 61 Medizin und Gesundheit :: 610 Medizin und Gesundheit, lipid metabolism, Hypertension, salt, QP1-981, Na
tonicity enhance binding protein (TonEBP)/nuclear factor of activated T-cells 5(NFAT5), peroxisome proliferator activator receptor (PPAR), Physiology, macrophage polarization, Macrophages, Peroxisome Proliferator-Activated Receptors, Sodium, Na+ storage, 610, Lipid Metabolism, angiogenesis, Adipose Tissue, Cardiovascular and Metabolic Diseases, arteriogenesis, DDC Classification::6 Technik, Medizin, angewandte Wissenschaften :: 61 Medizin und Gesundheit :: 610 Medizin und Gesundheit, lipid metabolism, Hypertension, salt, QP1-981, Na
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