Modulation of myocardial contraction by peroxynitrite

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2012Publisher:Frontiers Media SAJournal:Frontiers in Physiology, volume 3 (eissn: 1664-042X,

Copyright policy )Funded by:NIH | MEASUREMENT OF FREE RADIC..., NIH | NOS1/NOS3 Functional Effe..., NIH | Nitric oxide signaling in... +1 projects

Authors: Kohr, Mark J.; Roof, Steve R.; Zweier, Jay L.; Ziolo, Mark T.;

doi: 10.3389/fphys.2012.00468

pmid: 23248603

pmc: PMC3520483

Modulation of myocardial contraction by peroxynitrite

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Abstract

Peroxynitrite is a potent oxidant that is quickly emerging as a crucial modulator of myocardial function. This review will focus on the regulation of myocardial contraction by peroxynitrite during health and disease, with a specific emphasis on cardiomyocyte Ca(2+) handling, proposed signaling pathways, and protein end-targets.

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Keywords

cAMP-dependent protein kinase, nitric oxide synthase, Physiology, protein phosphatase 2a, peroxynitrite, Ca2+, Myocyte, QP1-981, Nitric Oxide Synthase, myocyte

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