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Frontiers in Oncology
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Frontiers in Oncology
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Flavonoids Inhibit Cancer by Regulating the Competing Endogenous RNA Network

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 18 Mar 2022Publisher:Frontiers Media SAJournal:Frontiers in Oncology, volume 12 (eissn: 2234-943X, Copyright policy )
Authors: Chengshun Li; Xiaolan Li; Ziping Jiang; Dongxu Wang; Liqun Sun; Jiaqi Li; Yang Han;

doi: 10.3389/fonc.2022.842790

pmid: 35371996

pmc: PMC8971295

Flavonoids Inhibit Cancer by Regulating the Competing Endogenous RNA Network

Abstract

Flavonoids are present in a wide range of plants. They have been used in the treatment of cancer, but the mechanism underlying this activity is unclear. In recent years, microRNA (miRNA) and long non-coding RNA (lncRNA) levels have been observed to differ between normal tissues and cancer cells, and both types of RNA have been shown to have a role in tumor treatment. In addition, flavonoids have been proven to regulate miRNAs and LncRNAs in the treatment of cancer. The competing endogenous RNA (ceRNA) network is a complex post-transcriptional regulatory mechanism in cells, in which coding and non-coding RNAs competitively bind miRNAs to regulate messenger RNAs (mRNAs). This review focused on the role of the ceRNA network in the treatment of cancer by flavonoids.

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Keywords

lncRNA, the competing endogenous RNA network, Oncology, gastric cancer, flavonoids, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, miRNA

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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 7
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
7
Top 10%
Average
Top 10%
Green
gold
Related to Research communities
Knowmad Institut
UArctic
Cancer Research