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The complex and adaptive nature of malignant neoplasm constitute a major challenge for the development of effective anti-oncogenic therapies. Emerging evidence has uncovered the pivotal functions exerted by the small leucine-rich proteoglycans, decorin and biglycan, in affecting tumor growth and progression. In their soluble forms, decorin and biglycan act as powerful signaling molecules. By receptor-mediated signal transduction, both proteoglycans modulate key processes vital for tumor initiation and progression, such as autophagy, inflammation, cell-cycle, apoptosis, and angiogenesis. Despite of their structural homology, these two proteoglycans interact with distinct cell surface receptors and thus modulate distinct signaling pathways that ultimately affect cancer development. In this review, we summarize growing evidence for the complex roles of decorin and biglycan signaling in tumor biology and address potential novel therapeutic implications.
ddc:610, 570, autophagy, proteoglycan, extracellular matrix, 610, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Medical Cell Biology, angiogenesis, Oncology, inflammation, Pathology, toll-like receptor, Medical Anatomy, cancer, RC254-282
ddc:610, 570, autophagy, proteoglycan, extracellular matrix, 610, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Medical Cell Biology, angiogenesis, Oncology, inflammation, Pathology, toll-like receptor, Medical Anatomy, cancer, RC254-282
citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 50 | |
popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Top 1% | |
influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Top 10% | |
impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Top 1% |