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The Fungal CYP51s: Their Functions, Structures, Related Drug Resistance, and Inhibitors

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 24 Apr 2019Publisher:Frontiers Media SAJournal:Frontiers in Microbiology, volume 10 (eissn: 1664-302X,

Authors: Jingxiang Zhang; Liping Li; Liping Li; Quanzhen Lv; Lan Yan; Yan Wang; Yuanying Jiang; +2 Authors

doi: 10.3389/fmicb.2019.00691

pmid: 31068906

pmc: PMC6491756

The Fungal CYP51s: Their Functions, Structures, Related Drug Resistance, and Inhibitors

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Abstract

CYP51 (Erg11) belongs to the cytochrome P450 monooxygenase (CYP) superfamily and mediates a crucial step of the synthesis of ergosterol, which is a fungal-specific sterol. It is also the target of azole drugs in clinical practice. In recent years, researches on fungal CYP51 have stepped into a new stage attributing to the discovery of crystal structures of the homologs in Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus. This review summarizes the functions, structures of fungal CYP51 proteins, and the inhibitors targeting these homologs. In particular, several drug-resistant mechanisms associated with the fungal CYP51s are introduced. The sequences and crystal structures of CYP51 proteins in different fungal species are also compared. These will provide new insights for the advancement of research on antifungal agents.

Related Organizations

Tongji University School of Medicine
China (People's Republic of)
Second Military Medical University
China (People's Republic of)
Indian Institute of Technology Kharagpur
India
Shanghai Tenth People's Hospital
China (People's Republic of)
Tongji University
China (People's Republic of)

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Keywords

resistance, crystal structure, azoles, CYP51, Microbiology, antifungal, QR1-502

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