The ability to better understand and predict the onset of antibiotic resistance to new drugs is needed. Antibiotic resistance has become an emerging issue of concern, and there are emphases to minimize its escalation. The number of cases of antibiotic resistant infections is increasing, as are the numbers of multidrug resistant bacteria. As a result, more antibiotics are becoming of limited use and previous attempts to tackle the resistance problem remain relatively ineffective. If we can more effectively anticipate how and when resistance is likely to arise, we can better manage drug use and perhaps extend efficacy of chemical treatment.