<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

The Role of CLEC-2 and Its Ligands in Thromboinflammation

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 09 Jun 2021Publisher:Frontiers Media SAJournal:Frontiers in Immunology, volume 12 (eissn: 1664-3224,

Authors: Beibei Liu; Danyang Meng; Man Luo;

doi: 10.3389/fimmu.2021.688643

pmid: 34177942

pmc: PMC8220156

The Role of CLEC-2 and Its Ligands in Thromboinflammation

- Summary
- Subjects
- Metrics

Abstract

C-type lectin-like receptor 2 (CLEC-2, also known as CLEC-1b) is expressed on platelets, Kupffer cells and other immune cells, and binds to various ligands including the mucin-like protein podoplanin (PDPN). The role of CLEC-2 in infection and immunity has become increasingly evident in recent years. CLEC-2 is involved in platelet activation, tumor cell metastasis, separation of blood/lymphatic vessels, and cerebrovascular patterning during embryonic development. In this review, we have discussed the role of CLEC-2 in thromboinflammation, and focused on the recent research.

Related Organizations

Jiaxing University
China (People's Republic of)
Groupe sur l'Immunité des Muqueuses et Agents Pathogènes
France

Keywords

Inflammation, Membrane Glycoproteins, Immunology, Anti-Inflammatory Agents, Thrombosis, RC581-607, Ligands, CLEC-2, podoplanin, Fibrinolytic Agents, inflammation, thromboinflammation, Animals, Humans, Lectins, C-Type, Immunologic diseases. Allergy, Inflammation Mediators, Blood Coagulation, thrombosis, Signal Transduction

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	44
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%