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Packaging of Non-Coding RNAs into Herpesvirus Virions: Comparisons to Coding RNAs

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2011Publisher:Frontiers Media SAJournal:Frontiers in Genetics, volume 2 (eissn: 1664-8021,

Copyright policy )Funded by:NIH | EXTRAMURAL RESEARCH FACIL..., NIH | Development of a Vaccine ..., NIH | EARLY MECHANISMS OF HIV T...

Authors: Melanie Ann Amen; Melanie Ann Amen; Anthony eGriffiths; Anthony eGriffiths; Anthony eGriffiths;

doi: 10.3389/fgene.2011.00081

pmid: 22303375

pmc: PMC3268634

Packaging of Non-Coding RNAs into Herpesvirus Virions: Comparisons to Coding RNAs

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Abstract

The herpesviruses are a family of large DNA viruses capable of establishing lifelong infections. Recent reports have shown that herpesviruses package non-coding RNA into virions; this follows earlier observations showing that coding RNAs are detected in virions. Packaging RNAs allows for their function immediately after virus entry and in the absence of de novo transcription. Despite the collective understanding that RNAs are packaged into herpesvirus virions, many questions remain. This review will highlight what is known regarding packaged coding and non-coding RNAs and discuss their potential impact to virus biology.

Related Organizations

The University of Texas Health Science Center at Houston
United States
The University of Texas Health Science Center at San Antonio
United States
TEXAS BIOMEDICAL RESEARCH INSTITUTE
Texas Biomedical Research Institute
United States

Keywords

virion, herpesvirus, mRNA, packaging, Virion, Genetics, RNA, QH426-470, miRNA

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