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Galanin Receptors and Ligands

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2012 Sweden Publisher:Frontiers Media SAJournal:Frontiers in Endocrinology, volume 3 (eissn: 1664-2392,

Authors: Webling, Kristin E. B.; Runesson, Johan; Bartfai, Tamas; Langel, Ülo;

doi: 10.3389/fendo.2012.00146

pmid: 23233848

pmc: PMC3516677

Galanin Receptors and Ligands

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Abstract

The neuropeptide galanin was first discovered 30 years ago. Today, the galanin family consists of galanin, galanin-like peptide (GALP), galanin-message associated peptide (GMAP), and alarin and this family has been shown to be involved in a wide variety of biological and pathological functions. The effect is mediated through three GPCR subtypes, GalR1-3. The limited number of specific ligands to the galanin receptor subtypes has hindered the understanding of the individual effects of each receptor subtype. This review aims to summarize the current data of the importance of the galanin receptor subtypes and receptor subtype specific agonists and antagonists and their involvement in different biological and pathological functions.

Country

Sweden

Related Organizations

University of Tartu
Estonia
Stockholm University
Sweden
University Institute of Technology, Burdwan University
India
Stockholm University
Sweden
Scripps Research Institute
United States

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Keywords

galanin, Epilepsy, galanin-like peptide, Alarin, Galanin, Kemi, Biological Sciences, RC648-665, GMAP, Diseases of the endocrine glands. Clinical endocrinology, Endocrinology, Chemical Sciences, alarin, epilepsy, Biologiska vetenskaper, Galanin-Like Peptide

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	125
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 1%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%