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PROTACs: The Future of Leukemia Therapeutics

descriptionPublicationkeyboard_double_arrow_right Article 02 Sep 2022 United Kingdom Publisher:Frontiers Media SAJournal:Frontiers in Cell and Developmental Biology, volume 10 (eissn: 2296-634X, Copyright policy )
Authors: Anwar, Zubair; Ali, Muhammad Shahzad; Galvano, Antonio; Perez, Alessandro; La Mantia, Maria; Bukhari, Ihtisham; Swiatczak, Bartlomiej;

doi: 10.3389/fcell.2022.851087

pmid: 36120561

pmc: PMC9479449

handle: 10447/580184

PROTACs: The Future of Leukemia Therapeutics

Abstract

The fight to find effective, long-lasting treatments for cancer has led many researchers to consider protein degrading entities. Recent developments in PROteolysis TArgeting Chimeras (PROTACs) have signified their potential as possible cancer therapies. PROTACs are small molecule, protein degraders that function by hijacking the built-in Ubiquitin-Proteasome pathway. This review mainly focuses on the general design and functioning of PROTACs as well as current advancements in the development of PROTACs as anticancer therapies. Particular emphasis is given to PROTACs designed against various types of Leukemia/Blood malignancies.

Country
United Kingdom
Related Organizations
Keywords

Cell and Developmental Biology, PROTACs, QH301-705.5, leukemia, cancer, anticancer therapeutics, Biology (General), linker

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 9
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
9
Top 10%
Average
Top 10%
Green
gold
Related to Research communities
Cancer Research