This article examines the current problem of the urogenital system morbidity in the city of Osh in the period from 2019 to 2023. Diseases of the genitourinary system pose a significant medical and social problem, especially in Kyrgyzstan, where regional climatic and socio-economic features affect the prevalence and nature of these diseases. The study is based on data from the Electronic Health Center of the Ministry of Health of the Kyrgyz Republic. The aim of the study is to analyze the dynamics and factors influencing the prevalence of diseases of the genitourinary system among various age groups in Osh over the specified period. The analysis includes the dynamics of morbidity among children, adolescents and adults, as well as the identification of the main factors influencing changes in indicators, including the COVID-19 pandemic. The most significant changes in morbidity rates were noted in 2020, when morbidity rates dropped sharply in all age groups, due tothe impact of the COVID-19 pandemic. This phenomenonhas been observed in many countries and is associated not only with the pandemic, but also withthe redistribution of health resources, delays in diagnosis and limited preventive measures. The work notes pronounced fluctuations in the incidence rate, a decrease in indicators in 2020 and a subsequent increase in 2022, due to pandemic restrictions and the resumption of normal operation of medical institutions. In addition, the article highlights the importance of developing preventive measures, including regular screenings, improving public health literacy, and taking regional factors into account. The results of the study are of practical importance for improving the diagnosis, prevention and treatment of diseases of the genitourinary system, which will improve the quality of life of the population.