Purpose: To evaluate the correlation between the degree of serous fluid and best corrected visual acuity at the first visit in central serous chorioretinopathy using optical coherence tomography. Methods: Retrospective analysis was performed for 30 eyes of 30 patients with central serous chorioretinopathy. Cross-sectional retinal images through the center of the fovea were obtained from all eyes by optical coherence tomography. The height, sectional area, and the tangent of theta (tan θ) were estimated. They were statistically analyzed and correlated with best corrected visual acuity. Results: Mean (±SD) height of serous fluid was 341.40±120.60 µm, mean (±SD) sectional area was 0.55±0.29 mm2, and mean (±SD) tan θwas 0.22±0.04. The correlation coefficients between best corrected visual acuity at the first visit and sectional area were r=-0.740 (P=0.001). Conclusions: Optical coherence tomography is useful for the quantitative evaluation of serous neurosensory retinal detachment and estimating visual acuity in central serous chorioretinopathy.