Effects of fenugreek (Trigonella foenugraecum Linn) on serum lipid profile in hypercholesteremic type 2 diabetic patients were studied. Administration of fenugreek seed powder of 25 g orally twice daily for 3 weeks and 6 weeks produces significant (p<0.001) reduction of serum total cholesterol, triacylglyceride and LDL-cholesterol in hypercholesteremic group but the change of serum HDLcholesterol was not significant. On other hand, changes of lipid profile in hypercholesteremic type 2 diabetic patients without fenugreek were not significant (p<0.001). The present study suggests that fenugreek seed powder would be considered as effective agent for lipid lowering purposes.