Kalanchoe pinnata (synonym to Byrophyllum pinnatum) or commonly known as “Setawar” is a medicinal plant belongs to the Crassulaceae family. It is also known as “life plant” and “resurrection plant” due to its multiple roles in traditional medication. The therapeutic values of K. pinnata mostly lie on the presence of phytochemicals or plant active compounds which possess high potential as a natural antimicrobial agent source. Given the global health threat of antimicrobial resistance towards synthetic drugs, uncovering the natural sources as a novel drug is of crucial need. In this regard this review highlights the antimicrobial property of K. pinnata extract, the bioactive compound analysis of this plant extract and their mode of action against pathogenic microorganisms. The potent bioactive compounds extracted from K. pinnata plant could be further explored as an alternative medicine to the current synthetic antimicrobial drugs.