The objective of the present article is to demonstrate the digital workflow used to manufacture an adjusted oral splint in a patient case.A 25-year-old female patient presented for management of her bruxism. Therefore, an adjusted oral splint was manufactured. A computer-aided motion analysis of the patient was conducted (JMA Optic). Full-arch scans of the maxilla and mandible, a biocopy of the maxilla with a bite fork, and buccal scans of the centric jaw relation (Primescan) were performed. The jaw relation was determined beforehand by ballistic closing on a chairside-fabricated anterior jig. The digital construction of a Michigan splint took place in the dental laboratory. The design was nested and milled from a polymethyl methacrylate (PMMA)-containing blank (CLEARsplint Disc).The oral splint was inserted into the patient's mouth and checked to ensure a tension-free fit. The static and dynamic contact relationship was checked. During the follow-up visit, the patient reported an improvement in tension in the masticatory muscles.The described procedure allows for the manufacture of an adjusted oral splint through a purely digital workflow.