This study aims to determine the influence of the Capital Adequacy Ratio (CAR) and Loan Deposit Ratio (LDR), both partially and simultaneously, on Non Performing Loans (NPL) in Conventional Commercial Banks in Indonesia for the period 2016-2020. This research is associative research with a quantitative approach. The data used in this study is secondary data, data analysis techniques using a data regression panel. Testing panel data include CEM, FEM and REM, Chow Test, Hausman Test, Lagrange Multiplier Test. Classic assumption tests include The Test of Normality, Heteroskedastisitas, Multicollinearity and Autocorrelation. Data analysis using correlation and determination coefficient analysis, Simultaneous and Partial Hypothesis Test. The population in this study was 99 Conventional Commercial Banks in Indonesia and a sample of 25 Conventional Commercial Banks in Indonesia with purposive sampling techniques. Based on the results of simultaneous hypothesis testing where CAR and LDR jointly have a significant effect on NPL Conventional Commercial Banks in Indonesia, the results off count 6.89 > 3.42 f table with a significant rate of 0.001457 lower than the α 0.05. While the partial hypothesis testing where CAR affects NPL Conventional Commercial Banks in Indonesia seen the results of t count -3,507 < 2,068 t table with a signifies value of CAR of 0.0006 is smaller than α 0.05. LDR has no effect on NPL of Conventional Commercial Banks with the calculation result of -1,116 < 2,068 t table with a significant LDR value of 0.2665 greater than α 0.05.