As outlined by the Council of Europe’s Reference Framework of Competences for Democratic Culture (RFCDC), civic competences are core elements for active participation in a democratic society. This study aimed to examine the linkages between four civic competences (empathy, respect, responsibility, and cooperation) and civic engagement (attitudes and behaviors) during adolescence, as well as test the potential role played by gender, both as a covariate and a moderator. We recruited a sample of 446 adolescents (70% females; M age = 16.51, SD = 1.35) from a high school in Southern Italy and administered a set of online self-report scales: civic attitudes and behaviors were evaluated through the Civic Engagement Scale; empathy was assessed through the Empathic Concern subscale of the Brief Interpersonal Reactivity Index; cooperation was assessed through the Cooperation Scale; responsibility and respect were measured through a set of descriptors provided by the RFCDC. A Structural Equation Model (SEM) was run to test the hypothesized associations, and a series of multiple group SEM was performed to evaluate the moderating role of gender on the relations between civic competences and civic engagement. Our findings showed only empathy and cooperation were positively and significantly related to civic attitudes and civic behaviors. Gender differences were found for empathy, cooperation, and respect, with girls reporting higher levels than boys. Adolescents’ gender was also found to be a significant moderator of relations linking empathy, cooperation and respect with civic engagement. Limitations and implications are discussed.