Objective: to analyze the impact of innovations on the productivity of pitahaya cultivation in the state of Puebla, Mexico. Design/ Methodology/ Approach: twenty-six pitahaya producers were surveyed in seven municipalities of Puebla. The profiles of producers were analyzed in terms of education and age. Thirty-six activities that influence crop productivity were evaluated, and the innovation adoption indices (InAI) and innovation adoption rates (IAR) were calculated. Results: the average IAR (innovation adoption rate) is below 40%. The application of organic matter as a soil amendment is the most widely adopted practice, while management and financial record-keeping are areas that producers have neglected. Crucial activities for improving productivity that producers should implement were identified, such as post-harvest fruit handling, pollination management, and genetic management. Our results suggest that these activities may be poorly executed. Limitations/ Implications of the study: the low availability of time of the producers and the large size of the area, generate difficulties for face surveys or more extent and frequent field visits. Findings/ Conclusions: a trend was found, although not universal, indicating that higher InAI is associated with higher crop yield. Therefore, the correct implementation of innovative activities is crucial for improving yield.